D-ガラクトサミン肝障害の進行に対する黄連解毒湯エキスの抑制効果

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We examined the preventive effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract (Tsumura TJ-15) on the progression of D-galactosamine (GAL)-induced liver injury in rats. In rats receiving a single intraperitoneal injection of GAL (500 mg/kg body weight), an apparent liver injury occurred 6 h after treatment and the liver injury progressed at 24 h, judging from the levels of serum liver cell damage markers such as aminotransferases, albumin, and triglyceride. Oral administration of TJ-15 (500 mg/kg body weight) to GAL-treated rats, which was conducted 6 h after hepatotoxin treatment, prevented liver injury progression observed at 24 h after hepatotoxin treatment. The hepatic concentrations of triglyceride and thiobarbituric acid reactive substances, an index of lipid peroxidation, and the hepatic activity of 5'-nucleotidase, a marker enzyme of plasma membranes, in GAL-treated rats increased 24 h, but not 6 h, after treatment. The hepatic activity of myelpoperoxidase, an index of tissue neutrophil infiltration, in GAL-treated rats increased 6 h after treatment and this increase in activity was enhanced at 24 h. The post-oral administration of TJ-15 attenuated all these changes observed at 24 h after GAL treatment. These results indicate that TJ-15 exerts a preventive effect on the progression of GAL-induced liver injury in rats possibly through its inhibitory actions against lipid peroxidation, triglyceride accumulation, plasma membrane destruction, and neutrophil infiltration in the liver tissue.
和漢医薬学会の論文
2002-12-20

D-ガラクトサミン肝障害の進行に対する黄連解毒湯エキスの抑制効果

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