COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 27)REPEATED TOXICITY STUDY ON ETHYLENE GLYCOL MONOMETHYL ETHER FOR 2 AND 4 WEEKS TO DETECT EFFECTS ON MALE REPRODUCTIVE ORGANS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
As part of a collaborative project to determine the minimum administration period to detect compound effects on male reproductive organs in Sprague-Dawley (Crj:CD(SD)) male rats, 6- and 8- week-old rats were administered ethylene glycol monomethyl ether (EGME) daily at 100 and 200 mg/kg/day for 2 weeks or 100 mg/kg/day for 4 weeks, and histopathological changes in the testes and epididymides were examined. Testis and epididymis weights in the 2-week 200 mg/kg and 4-week 100 mg/kg groups were obviously decreased. On histopathological examination, severe degenerative changes in the testis such as atrophy of the seminiferous tubules and multinucleated giant cell formation were observed in all 2-week 200 mg/kg group rats. Degeneration of pachytene spermatocytes in Stages X IV-II, III and a decrease in the number of germ cells was observed with both 2 and 4 weeks treatments at 100 mg/kg/day. In the epididymides, the number of sperm in the caput decreased with 100 mg/kg/day groups after both 2 and 4 weeks. In addition, degeneration of pachytene spermatocytes induced by EGME was found to be exclusively due to apoptotic death. Similar testicular and epididymal changes were observed with 2 and 4 weeks treatments at 100 mg/kg/day of EGME. Therefore, we conclude that a 2 weeks administration period is sufficient for detection of EGME effects on male reproductive organs.
- 日本トキシコロジー学会の論文
- 2000-10-25
著者
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Sato Norihiro
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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WATANABE Atsushi
Laboratory for Toxicological Research, Institute for Life Sciences Research, Asahi Cheimical Industr
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NAKANO Yuji
Laboratory for Toxicological Research, Institute for Life Sciences Research, Asahi Cheimical Industr
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ENDO Takako
Laboratory for Toxicological Research, Institute for Life Sciences Research, Asahi Cheimical Industr
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KAI Kiyonori
Laboratory for Toxicological Research, Institute for Life Sciences Research, Asahi Cheimical Industr
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SHIRAIWA Kazumi
Laboratory for Toxicological Research, Institute for Life Sciences Research, Asahi Cheimical Industr
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Endo Takako
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Nakano Yuji
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Kai Kiyonori
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Sato Norihiro
Laboratory For Safety Assessment & Adme Pharmaceuticals Research Center Asahi Kasei Pharma Corpo
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WATANABE Atsushi
Institute of Seismology and Volcanology, Faculty of Sciences, Kyushu University
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Shiraiwa Kazumi
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Endo T
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Watanabe A
Institute Of Seismology And Volcanology Faculty Of Sciences Kyushu University
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Watanabe Atsushi
Laboratory For Safety Assessment & Adme Pharmaceuticals Research Center Asahi Kasei Pharma Corpo
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Endo Toru
Dept. Of Pharmacol. Facul. Of Pharm. Sci. Hlth Sci. Univ. Of Hokkaido
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Sato Norihiro
Pharmaceuticals Research Center Asahi Kasei Pharma Corporation
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Shiraiwa Kazumi
Laboratory For Toxicological Research Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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Kai Kiyonori
Laboratory For Toxicological Research Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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