COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 5)EFFECTS OF REPEATED DOSES OF FLUTAMIDE FOR 2 AND 4 WEEKS
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概要
- 論文の詳細を見る
Flutamide, a nonsteroidal antiandrogen, was administered orally to 8-week (for the 2 week study) and 6-week-old (for the 4 week study) male Crj:CD(SD) rats at dose levels of 0 mg/kg, 60 mg/kg and 200 mg/kg daily for 2 weeks or 4 weeks in order to determine whether a 2 week treatment period is sufficient for detection of drug effects on the male reproductive system. Flutamide treatment for 4 weeks resulted in decreased organ weights of the epididymides and prostate, decreased sperm counts and Leydig cell proliferation in the testes at 60 mg/kg and 200 mg/kg. Decreased sperm motility and histological lesions in the seminiferous tubules were observed at 200 mg/kg. FIutamide treatment for 2 weeks decreased organ weight of epididymides and prostate and caused Leydig cell proliferation in the testes at 60 mg/kg and 200 mg/kg. Decreased sperm counts and sperm motility, and histological lesions in seminiferous tubules were observed at 200 mg/kg. The results of this study showed that 2 weeks treatment with flutamide causes histological lesions of testes and disorders of sperm parameters similar to those observed with 4 weeks treatment, indicating that 2 weeks treatment is sufficient for detection of effects of flutamide on the male reproductive system.
- 日本トキシコロジー学会の論文
- 2000-10-25
著者
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Sakai Eiko
九州大学 歯学部小児口腔医学
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Sakai H
Osaka Univ. Osaka
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Sakamoto Hironori
Department Of Material Physics Faculty Of Engineering Science Osaka University
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Nomura Akio
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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Sakamoto H
Department Of Material Physics Faculty Of Engineering Science Osaka University
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Sakamoto H
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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OKAHARA Akihiko
Santen Pharmaceutical Co., Ltd., Developmental Research Division
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TANIOKA Hidetoshi
Santen Pharmaceutical Co., Ltd., Developmental Research Division
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SAKAMOTO Hiroshi
Santen Pharmaceutical Co., Ltd., Developmental Research Division
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YAMASHITA Kiyoko
Santen Pharmaceutical Co., Ltd., Developmental Research Division
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IKUSE Toshimi
Santen Pharmaceutical Co., Ltd., Developmental Research Division
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Ikuse T
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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Yamashita Kiyoko
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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Tanioka Hidetoshi
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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Okahara A
Santen Pharmaceutical Co. Ltd. Developmental Research Division
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- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 5)EFFECTS OF REPEATED DOSES OF FLUTAMIDE FOR 2 AND 4 WEEKS
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