SEX DIFFERENCES IN IMMUNE RESPONSES TO CEPHALOTHIN IN GUINEA PIGS

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概要

• 論文の詳細を見る

• Guinea pigs of two strains, outbred Hartley and inbred Strain 2, were immunized sub-cutaneously with cephalothin (CET, 20 mg/body) alone, without adjuvant. Immune responses to the antibiotic were assessed by guinea-pig passive cutaneous anaphylaxis (GP-PCA) and active systemic anaphylaxis (GP-ASA) reactions. The immune response to CET in the female Hartley guinea pigs was higher than that in the males. In contrast, no difference in response to CET in Strain 2 guinea pigs was observed between males and females. These results suggested that female Hartley guinea pigs possessing a higher response should be employed in antigenicity studies involving the β-lactam antibiotics.

• 1998-02-13

著者

• Ishikawa Nobuhiro

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

• Aida Tetsuo

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

• Shinkai K

  Japan Pharmaceutical Manufacturers Assoc. Tokyo Jpn

• Shinkai Kenkichi

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

関連論文

• SEX DIFFERENCES IN IMMUNE RESPONSES TO CEPHALOTHIN IN GUINEA PIGS
• EVALUATION OF ALLERGENIC POTENTIAL OF LOW-MOLECULAR COMPOUNDS BY MOUSE POPULITEAL LIMPH NODE ASSAY
• INFLUENCE OF HMG-COA REDUCTASE INHIBITORS ON PLAQUE-FORMING CELL (PFC) RESPONSE IN MICE
• DIFFERENCES IN IMMUNE RESPONSES TO ANTIBIOTICS IN THREE GUINEA-PIG STRAINS
• DIFFERENCES IN IMMUNE RESPONSES TO A LOW-MOLECULAR COMPOUND IN THREE GUINEA-PIG STRAINS

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