DIFFERENCES IN IMMUNE RESPONSES TO A LOW-MOLECULAR COMPOUND IN THREE GUINEA-PIG STRAINS

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概要

• 論文の詳細を見る

• The present experiments were undertaken to clarify the differences in humoral and cellular immune responses to a low-molecular compound, sodium 2,4,6-trini-trobenzenesul fonate dihydrate (TNBS) in guinea-pig strains. Guinea pigs of three different strains, Hartley, Strain 2 and Strain 13, were immunized subcutaneously with TNBS (3mg/body) 2 or 3 times a week, 9 times in total. Humoral immune responses to TNBS were assessed by passive cutaneous anaphylaxis (PCA) and Arthus reaction, and cellular immune response was assessed by delayed-type hypersensitivity (DTH). Hartley guinea pigs showed high humoral immune responses to TNBS, whereas Strain 2 and 13 guinea pigs showed low responses. Strain 2 guinea pigs displayed high cellular immune response to TNBS, and Strain 13 displayed low cellular immune responses. These results suggest that the pattern of humoral immune response to TNBS does not correlate with that of the cellular immune responses to TNBS for Strain 2 and Hartley guinea pigs.

• 日本トキシコロジー学会の論文
• 1997-05-25

著者

• Ishikawa Nobuhiro

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

• Aida Tetsuo

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

• Shinkai K

  Japan Pharmaceutical Manufacturers Assoc. Tokyo Jpn

• Shinkai Kenkichi

  Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.

関連論文

• SEX DIFFERENCES IN IMMUNE RESPONSES TO CEPHALOTHIN IN GUINEA PIGS
• EVALUATION OF ALLERGENIC POTENTIAL OF LOW-MOLECULAR COMPOUNDS BY MOUSE POPULITEAL LIMPH NODE ASSAY
• INFLUENCE OF HMG-COA REDUCTASE INHIBITORS ON PLAQUE-FORMING CELL (PFC) RESPONSE IN MICE
• DIFFERENCES IN IMMUNE RESPONSES TO ANTIBIOTICS IN THREE GUINEA-PIG STRAINS
• DIFFERENCES IN IMMUNE RESPONSES TO A LOW-MOLECULAR COMPOUND IN THREE GUINEA-PIG STRAINS

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