NON-UROTOXIC INDUCTION OF HEMORRHAGIC CYSTITIS BY BRAXIN C, A BRACKEN TOXIN, IN GUINEA PIGS
スポンサーリンク
概要
- 論文の詳細を見る
Single subcutaneous injections of 5 and 10 mg/kg of braxin C (BC), ptaquiloside, a toxin isolated from bracken fern, have been shown to induce hemorrhagic cystitis in guinea pigs. In order to determine whether the hemorrhagic cystitis induced by BC is due to the urotoxic effects or not, BC was administered to the guinea pigs in which the flow of urine to the urinary bladder had been intercepted by cannulation of the ureters under anesthesia. In the animals treated ureteral cannulation, edema and hemorrhage were observed in the urinary bladder following BC administration (10 mg/kg s.c.). These findings suggest that BC induced hemorrhagic cystitis is mediated by hematogenous and not urotoxic factors.
- 日本トキシコロジー学会の論文
- 1994-05-25
著者
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SAITO Toshiyuki
Department of Oral Health, Nagasaki University Graduate School of Biomedical sciences
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Yoshida Masaru
Department Of Gastroenterology Kobe University Hospital
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Yoshida Masaru
Department Of Veterinary Pharmacology Faculty Of Agriculture Tottori University
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Saito Toshiyuki
Department Of Anatomy Nippon Medical Scool
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Yoshida Masaru
Department of Biochemical Science,Faculty of Computer and Systems,Engineering,Kyushu Institute of Technology
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