MUTAGENIC AND CLASTOGENIC PROPERTIES OF (3-[3-(6-BENZOYLOXY-3-CYANO-2-PYRIDYLOXYCARBONYL)BENZOYL]-1-ETHOXYMETHYL-5-FLUOROURACIL)(BOF-A2), A NEW 5-FLUOROURACIL DERIVATIVE WITH ANTI-TUMOUR ACTIVITY
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概要
- 論文の詳細を見る
As part of the safety assessment of (3-[3-(6-benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl]-1-ethoxymethyl-5-fluorouracil)(BOF-A2), a new 5-fluorouracil (5-FU) derivative with anti-tumour activity, its potential genotoxicity was studied in 3 different tests. BOF-A2 was negative in a reverse mutation (Ames) test in strains of S. typhimurium and E. coli. BOF-A2 induced chromosomal aberrations in Chinese hamster cells in vitro especially in the presence of exogenous metabolic activation, and was clastogenic in vivo, inducing micronuclei in mouse bone marrow. The clastogenic activity of BOF-A2 was similar to that of 5-FU.
- 日本トキシコロジー学会の論文
著者
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Kirkland David
Hazleton Microtest
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Ito T
Kyowa Hakko Kogyo Co. Ltd. Yamaguchi Jpn
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Takahashi Nobuo
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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SHIBAHARA Toshikazu
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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KANEKO Etsuko
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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ITOH Toshiaki
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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AWOGI Takumi
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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TSUSHIMOTO Gen
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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MARSHALL Richard
Hazleton Microtest
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Awogi Takumi
Department Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Kaneko Etsuko
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Tsushimoto Gen
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Itoh Tadanobu
Department Of Pharmacology School Of Dentistry Iwate Medical University
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Shibahara Toshikazu
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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