DNA-DAMAGING, MUTAGENIC, CLASTOGENIC AND CELL-CELL COMMUNICATION INHIBITORY PROPERTIES OF γ-ORYZANOL
スポンサーリンク
概要
- 論文の詳細を見る
As a part of short-term safety assessment of γ-Oryzanol, the genotoxic or the carcinogenic initiation activity was studied in three genetic toxicity tests and the promotion activity was studied in a cell-cell communication inhibitory test. γ-Oryzanol showed the negative response in the bacterial DNA repair test (Rec-assay), the bacterial reverse mutation tests (Ames test) and the rat bone marrow chromosome aberration test. Also, γ-Oryzanol showed the negative response in the metabolic cooperation inhibition test using Chinese hamster V79 cells.
- 日本トキシコロジー学会の論文
- 1991-11-25
著者
-
Yamamoto Kyoko
Biological Science Research Institute Nomura Research Institute
-
SHIBAHARA Toshikazu
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
-
AWOGI Takumi
Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
-
Awogi Takumi
Department Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Kaneko Etsuko
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Tsushimoto Gen
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
SUTOU Sizuyo
Biological Science Research Institute, Nomura Research Institute
-
SHIRAKAWA Haruko
Biological Science Research Institute, Nomura Research Institute
-
Shibahara Toshikazu
Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Sutou Sizuyo
Biological Science Research Institute Nomura Research Institute
-
Shirakawa Haruko
Biological Science Research Institute Nomura Research Institute
関連論文
- MUTAGENIC AND CLASTOGENIC PROPERTIES OF (3-[3-(6-BENZOYLOXY-3-CYANO-2-PYRIDYLOXYCARBONYL)BENZOYL]-1-ETHOXYMETHYL-5-FLUOROURACIL)(BOF-A2), A NEW 5-FLUOROURACIL DERIVATIVE WITH ANTI-TUMOUR ACTIVITY
- Nuclear localization of alkaline phosphatase in cultured human cancer cells
- DNA-DAMAGING, MUTAGENIC, CLASTOGENIC AND CELL-CELL COMMUNICATION INHIBITORY PROPERTIES OF γ-ORYZANOL