INVOLVEMENT OF CHOLINERGIC MECHANISM IN THE ACTION OF ALLETHRIN IN INSECT CNS

概要

論文の詳細を見る
Allethrin had a stimulating action on spontaneous discharges in the cockroach sixth abdominal ganglion superfused with an insect saline solution. This action at a low concentration (5x10^<-8>M) of allethrin was abolished by either of d-tubocurarine, hexamethonium or atropine at 5x10^<-4>M. It was also abolished by the treatment of ganglia with hemicholinium-3 or by low-calcium-high magnesium insect saline solution. However, treatment of these blocked ganglia with allethrin at more than 5x10^<-7>M overcame the block, producing increased spontaneous activity. Allethrin had no effect on insect cholinesterase activity. These results may suggest that the stimulating action at a low concentration of allethrin may be mediated by the release of ACh from cholinergic terminals in ganglia.
日本トキシコロジー学会の論文
1983-11-25