NASAL LESIONS INDUCED BY INTRANASAL ADMINISTRATION OF BENZALKONIUM CHLORIDE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the lesions of nasal cavity mucous membrane caused by administration of 0.01, 0.05 and 0.10 w/v% Benzalkonium chloride (BZC) solutions in the nasal cavity of rats. No BZC-induced symptoms or nasal lesions were seen in the 0.01 w/v% BZC-treated group. On the other hand, BZC-induced symptoms such as nasal sound and rubbing the nose with forelegs were observed in the 0.05 and 0.10 w/v% BZC-treated groups. Additionally, BZC-induced lesions, including epithelial desquamation, inflammation and edema, occurred in the anterior nasal cavity in the 0.05 and 0.10w/v% BZC-treated groups, but these lesions were confined to the dorsal meatus and the adjacent nasal septum. These results indicate that 0.01 w/v% BZC solution has no effect on the nasal cavity mucous membrane. However, 0.05 and 0.10 w/v% BZC solutions induce lesions in the nasal cavity mucous membrane due to their irritating effect.
- 日本トキシコロジー学会の論文
- 1997-05-25
著者
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Hara T
Inst. Whole Body Metabolism Chiba Jpn
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HARA Takuji
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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SUZUKI Kazuo
Toxicological Research Laboratories, KYOWA HAKKO KOGYO CO., LTD.
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Suzuki K
Nippon Veterinary And Animal Sci Univ. Tokyo Jpn
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Hara Takuji
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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KUBOYAMA Yasumasa
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Kuboyama Yasumasa
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Suzuki Kazuo
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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