徐放性モルヒネ錠内包坐剤投与によるモルヒネの患者血中濃度と鎮痛効果

概要

論文の詳細を見る
In preparation for a study, we prepared a morphine suppository (MS-C suppository) that contained controlled-release morphine tablet (MS Contin^<[O!R]>) in the suppository base. We then investigate plasma morphine concentrations and the analgesic effect produced following rectal MS-C suppository were investigated in three patients with cancer pain. Plasma morphine concentrations subsequent to this rectal administration were found to be much higher than those predicted from the morphine concentration administered orally. The elimination half-life of morphine (t_<1/2>) after rectal administration was 2.5-4 times longer than that after oral administration of MS Contin^<[O!R]>. The clinically desirable analgesic effect was obtained in all patients tested. Though side effect of drowsiness was observed in two patients. These results indicated that the MS-C suppository is a desirable treatment for ameliorating cancer pain.
日本医療薬学会の論文
1998-04-10