フィトナジオン輸液の光安定化設計 : 脂溶性ビタミンの添加による光分解抑制効果

概要

論文の詳細を見る
One of three fat-soluble vitamins, tocopherol, ubidecarenone, and retinol palmitate was added to improve the photostability of vitamin K_1 (K_1) in model infusion fluids. The time courses of photodegradation of K_1 and the vitamin added in infusion fluid under the irradiation of monochromatic light or fluorescent lamp were followed by using high-performance liquid chromatographic method. K_1 and retinol palmitate in infusion fluid were more photolabile within the wavelength range of 300-400 nm, while tocopherol and ubidecarenone were stable at wavelengths above 320 nm. The photolytic degradation of K_1 was inhibited most effectively by the addition of ubidecarenone, whereas no satisfactory inhibition effect was obtained for tocopherol. The degradation rate constant of K_1 decreased remarkably with the increase in amount of ubidecarenone added. The photostabilizing effect was thus closely related to the photostability and light absorption properties of the vitamins added.
日本医療薬学会の論文
1996-10-10