イソニアジドメタンスルホン酸ナトリウム・リン酸ピリドキサールカルシウム散の着色変化に及ぼす混合様式の影響

概要

論文の詳細を見る
The effect of grinding on the coloration of the isoniazid sodium methanesulfonate (IHMS) and pyridoxal calcium phosphate (PAL-P-Ca) compound was investigated using three types of mixers, namely a twin -shell mixer, a ball mill, or a chaser mill. The color of the compound powder became an intense yellow with increase in the mixing time when the ball or chaser mill was employed. Conversely, mixing using the twin-shell mixer did not significantly affect the color of the compoud powder. The color difference before and after mixing,ΔE, of PAL-P-Ca itself increased with prolonged mixing by the ball mill. The results of X-ray powder diffraction analysis of the ground PAL-P-Ca powder suggested that the crystallinity of the drug decreased.The dehydration temperature of the ground PAL-P-Ca decreased with the increase in grinding time by mechanochemical stress, while the chemical stability of the drug was not affected. These results suggest that the coloration of PAL-P-Ca crystals under mechanical stress are closely related to a change in physicochemical properties (water content, dehydration temperature and crystallinity).
日本医療薬学会の論文
1996-04-10