Differences among Decoction Methods in the Composition of Alkaloids in Decoctions Produced from Sen-uzu, Aconitum Root

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Differences between the decoction methods amounts of alkaloids in decoctions from Aconitum root was investigated in the differing decoction apparatus (electric decoction unit, enameled pot or an earthen pot conditions), filtrations and temperatures (25, 40 or 97℃). Aconitine-type alkaloids (aconitine, mesaconitine and hypaconitine) and total alkaloids were measured by HPLC and titration, respectively. The filtrations and temperatures conditions did not affect the amount of aconitine-type and total alkaloids. The amount of mesaconitine in the decoction with an enameled pot was significantly lower than in the other apparatuses, but the amount of total alkaloids was the same as in the other apparatus. It is recommended producing decoction be done with an enameled pot followed by immediate filtration from the standpoint of decreasing the toxicity of Aconitum root which constitutes several Chinese medicines.
日本医療薬学会の論文
1995-12-10