分割錠剤の設計と評価

概要

論文の詳細を見る
Various types of scored tablets were designed and evaluated in terms of ease of divisibility and weight variation of the two halves following the division. Tablets were prepared with a standard one-face score(I), a standard one-face score with side scores(II), a uniform all-around score(III), a standard one-face score with deep side scores(IV), an all-around score with deep side scores(V) and a deep one-face(VI). From the comparison of tablets I & VI, it was found that when the depth of the score was 30% of the tablet thickness, the tablets were easily divided by hand into two equal halves with a small weight variation. However, tablet VI was found to have a disadvantage with regard to practical production: the durability of the punched heads was not satisfactory. For an all-around score, the optimal ratio of the depth of the score on the side to the length on the face was found to fall within the 8 to 20% range. Tablets III and V were found to be easily and precisely divided [weight variation (CV): 5%>]. Our study clarified that the design of the score greatly affects the ease of divisibility of scored tablets as well as the weight variation of the two halves following the division.
日本医療薬学会の論文
1993-08-20