セレポート^<[○R!]>顆粒の可溶化と安定性
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概要
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Celeport^<[○R!]> granules (preparation of bifemelane hydrochloride) is a cerebral metabolic activator developed for disturbance of cerebral circulation. For the purpose of per tubam medication with Celeport^<[○R!]> granules of which exterior coat was insoluble in water, we attempted to prepare Celeport^<[○R!]> solution with citric acid. Celeport^<[○R!]> granules was well disintegrated with citric acid solution at concentration above 0.5%w/v. Stability of Celeport^<[○R!]> solution(0.5% citric acid solution) and compatibility tests of six kinds of medicine in combination with Celeport^<[○R!]> solution were investigated with regard to change in appearance, pH value and bifemelane content. In these compatibility tests, the following commercially available medicines were used:ground Avan^<[○R!]> tablets, diphenylhydantoin powder, Hicee^<[○R!]> granules, Hyserenin^<[○R!]> fine granules, Perdipine^<[○R!]> powder and Clinimeal^<[○R!]> . No change was observed in Celeport^<[○R!]> solution alone, but when admixed with other medicines, decrease of bifemelane content was found in all cases. In the combination with either ground Avan^<[○R!]> tablets, Hyserenin^<[○R!]> fine granules, or Perdipine^<[○R!]> powder, changes in appearances were observed. Furthermore, in the combination with Hyserenin^<[○R!]> fine granules, shift of pH value to alkalinity occured. These results suggest that single dispensation might be desirable for administration of Celeport^<[○R!]> solution.
- 日本医療薬学会の論文
- 1990-12-20
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