急性脳障害に対するサイアミラール投与計画 : 高速液体クロマトグラフィーによるサイアミラール濃度測定とその臨床応用

概要

論文の詳細を見る
Thiamylal in plasma was measured by using high-performance liquid chromatography (HPLC). Thiamylal was extracted from human plasma with acetonitrile containing phenacetin as an internal standard, and it was chromatographed on a reverse phase column (Lichrosorb RP-18) with a mobile phase of acetonitrile/0.05M NaH_2PO_4 (60:40). The recovery from plasma lied between 98.8-104.0%. Plasma thiamylal concentrations of two patients were measured. Thiamylal concentration in plasma was maintained for 8 to 72 hours after administration at the level of 12-17μg/ml. The elimination rate constant (Ke) was 0.059±0.017hr^-1 and biological half-life (t1/2) was 12.9±3.5hr^-1 (mean±S.D.) in four patients.
日本医療薬学会の論文
1988-08-20