無菌製剤処理化高カロリー輸液剤でのビタミンの長期安定性に関する薬剤学的研究

概要

論文の詳細を見る
For the purpose of supply of intravenous hyperalimentation solutions (IVH) for home care, we examined long-term stability, especially vitamins B_1, B_2, C and A for two weeks to monitor changes in hospital coded prescription, IVH 1-5. Decrease of vitamin B_1 was observed in IVH 1-4 with time. It was decreased by 27.0-40.5% on the 14th day, while in IVH 5 the concentration decreased to at 83.7%. Vitamin C showed the next largest decrease to 65.1% being retained two weeks in IVH 5. In IVH 1-4, on the other hand, it remained at 83.6-94.4%. Other two vitamins B_2 and A remained stable at the comparatively high level of 80.9-101.4% in each preparation. From the results, it is seemed that if the constituents of IVH are given sufficient consideration, it would be possible to guarantee the long-term stability of IVH with vitamins in the index of vitamins B_1 and C.
日本医療薬学会の論文
1988-10-20