ストレプトマイシンの血中濃度測定とファーマコキネティクス : 有効治療と副作用軽減のために

概要

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Serum streptomycin (SM) concentrations in patients with pulmonary tuberculosis were determined by fluorescence polarization immuoassay (FPIA) method, and the relationships between the pharmacokinetics and the side effects of SM were investigated. SM clearance correlated with that of creatinine. However, some nonlinear pharmacokinetics were observed in patients who are over 60 years old and have less than 50 ml/min of Clcr, suggesting the relation to the appearance of the toxicity of SM. There was a tendency for the increase of oto-toxicity in patients with over 3 hrs of half-life (t_<1/2>) or over 35-50 μg/ml of maximum concentrations (C_<max>). It was suggested that the determination of serum SM concentration at 1 hr after intramuscular injection is important to avoid the appearance of the toxicity, since it correlated with C_<max> and SM clearance.
日本医療薬学会の論文
1986-12-20