ウロキナーゼ活性におよぼす輸液の影響

概要

論文の詳細を見る
Stability of urokinase activity in the presence of following adjuncts was studied in various infusions at room temperature : mannitol, human serum albumin (albumin) and hydrogenated castor oil polyoxyethylene 60 mole ether (HCO-60). Urokinase activity was stable in the saccharum infusions. In the electrolyte infusions the activity was immediately and considerably decreased but recovered to the level of the control by dialysis. As a result of the analysis of variance of adjunct effect, it was suggested that urokinase activity in the presence of albumin was more stable than in the presence of mannitol. Albumin and HCO-60 prevented urokinase from adsorbing to plastics and glass in the rotation, vibration and drip infusion test by the tube method. Albumin is a human protein having no blood coagulation factor, while HCO-60 has unknown pharmacological action. For this reason, albumin is a better adjunct to urokinase than mannitol and HCO-60.
日本医療薬学会の論文
1977-11-20