The Role of Substance P in Parasympathetic Nerve-induced Secretion in the Rat Submandibular Gland

スポンサーリンク

概要

• 論文の詳細を見る

• Fluid secretion from rat submandibular saliva evoked by electrical stimulation of the chorda tympani (parasympathetic secretory stimulation) was greatly reduced in the presence of atropine. However, some secretion was always evident at frequencies of 5Hz and higher. The substance P-antagonist ([D-Arg^1, D-Pro^2, D-Trp^<7,9>, Leu^<11>]-substance P) also reduced the chorda-evoked saliva. Salivary secretion induced by the electrical stimulation of the superior cervical ganglion (sympathetic secretory nerve) was not affected by either atropine or substance P-antagonist. Continuous chordal stimulation reduced the glandular content of substance P to approximately 50% after 60 min, but similar stimulation of the superior cervical ganglion failed to produce such a reduction. Electron histochemical observation showed that the chordal stimulation caused depletion of substance P from the appropriate nerve fibers within the gland. The reduced secretory capability after continuous stimulation of the chorda at high frequency (20Hz) was reversed by infusion of a subthreshold dose of exogenous substance P. Histological examination of granular duct cells revealed no degranulation in either chorda-stimulated or substance P-infused rats. The summation of findings suggests that endogenous substance P plays a complementary role in the regulation of parasympathetic nerve-induced fluid secretion in the acinus but is minimally involved in degranulation from granular duct cells.

• 大阪歯科学会の論文

著者

• Takai Noriyasu

  Department Of Physiology Osaka Dental University

• SUGISAWA Michimori

  Department of Physiology, Osaka Dental University

• Sugisawa Michimori

  Department Of Physiology Osaka Dental University

関連論文

• Inhibitory regulation by GABA_A receptors in the rat submandibular gland
• Effect of aquaporin 5 on paracellular water secretion in rat submandibular gland acini
• Regulation by Cholecystokinin in Chorda-induced Salivary Secretion in the Rat Submandibular Gland
• Opened and Closed States of Tight Junctions by Secretory Stimuli in Rat Submandibular Acini
• The Influence of Physical Stress on Amylase Activity in Human Saliva
• Secretory regulation by cholecystokinin in the rat submandibular gland
• The Role of Substance P in Parasympathetic Nerve-induced Secretion in the Rat Submandibular Gland
• Autonomic Regulation of Tight Junctional Permeability in the Rat Submandibular Gland

スポンサーリンク