活性酸素による突然変異誘発機構 : 大腸菌の鉄の取り込み調節機能とその活性酸素防御としての役割 : 第12回公開シンポジウム : 活性酸素の分子病態学

概要

論文の詳細を見る
It is generally accepted that iron is one of the most important metals for microorganisms, because it is essential as a co-factor for a number of enzymes involved in cellular metabolism. However, it is not easily available to them due to its insolubility in aerobic environments. In order to acquire iron, microorganisms have evolved iron transport systems wherein so-called siderophores -low molecular weight compounds- are secreted and which function to chelate iron with high affinity. In addition to the iron transport systems, they also have a genetic regulation system in which a regulatory protein can sense the cellular level of iron and controls the gene expression of transport systems. While iron is essential, excess iron is toxic due to its ability to catalyze Fenton reactions that produce hydroxyl radicals. Thus, these iron-uptake-systems have important roles in prevention of both iron starvation and oxidative stress. Here we describe the gene regulation of iron-uptake-systems and their roles in protection from oxidative mutagenesis.
日本環境変異原学会の論文
2001-12-22