A micronucleus study of 2-methyl aziridine (propyleneimine) in rat peripheral blood and bone marrow by 4-week repeated exposure

概要

論文の詳細を見る
Micronucleus induction in rat peripheral blood and bone marrow cells was studied after a 4-week repeated exposure to 2-methyl aziridine (2MA). 2MA was administered daily at 0, 2.5, 5, 10, and 20 mg/kg/day by oral gavage for 28 consecutive days. The peripheral blood samples were prepared on days 2, 3, 7, 14, 21, and 28 after the first administration, and bone marrow samples were prepared at 24 hours after the last administration. 2MA significantly induced micronucleated reticulocytes (MNRET) at 20 mg/kg/day and with two peaks at days 2 and 21. The time course and absolute values of the frequency of these MNRET were the same for micronucleated bone marrow cells. These findings therefore suggest that the micronucleus test with peripheral blood may be used as an alternative to the bone marrow micronucleus test in long-term toxicological assays in rats.
日本環境変異原学会の論文
2000-02-28