内分泌撹乱化学物質がもたらす遺伝的不安定性 : 組換え型遺伝子突然変異について : 第10回公開シンポジウム : 内分泌撹乱物質の作用機序と後世代影響 : 環境変異原研究との接点

概要

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Endocrine disruptor chemicals (EDCs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have become significant environmental pollutants from industrial processes. They can affect hormonal receptors agonistcally or antagonistically and can disrupt endocrine systems, Ieading to disorders including sexual organ aplasia, spermatogenic and oogenic hypoplasia, genital cancers, and others. Although most EDCS yielded a negative response in most short-term genotoxicity assays including the Ames (Salmonella) test, some induced genomic instability by elevating the frequency of recombination. Thus, EDCS do not seem to act as classical genotoxins. We briefly review here the recombinogenic activity of EDCS and its association with carcinogenesis, and suggest a need for systematic methods to screen, rank, and identify the genotoxicity of EDCs. (This paper, chaired by Kiyomi Kikukawa, was presented to the 10th JEMS Annual Symposium, "Endocrine Disruptor Mechanism and Posterity Effects-Concern with Environmental Mutagen Research", organized by Kiyomi Kikukawa, Tohru Shibuya, and Kazuo Fujikawa, sponsored by the Environmental Mutagen Society of Japan, and held at The Pharmaceutical Society of Japan, Nagai Memorial Hall, May 28, 1999.)
日本環境変異原学会の論文
1999-10-29