はじめに : 癌原性物質検出系としての細胞形質転換試験の現状

概要

論文の詳細を見る
Genotoxicity test batteries have become a standard tool for identifying chemicals that have potential carcinogenic risk to humans. Their use for assessing carcinogenic potential, however, has limitations such as an overall low specificity and negative detection of non-mutagenic carcinogens. In vitro cell transformation models, employing Syrian hamster embryo cells, BALB/c 3T3 cells or C3H10T1/2 cells, have been recognized as being relevant to carcinogenesis and regarded as useful tools for predicting carcinogenic potential of chemicals and for studies on the mechanisms of action of carcinogens and carcinogenic processes. In spite of the expectation, their use for screening carcinogens has not been fully exploited. Some difficulties still exist in employing them as a routine procedure. It seems that further improvement of the methods and further studies on detailed mechanisms of cell transformation are still necessary. In this symposium, speakers presented studies on methods improvement and on mechanisms of cell transformation, and discussed the advantages in predicting carcinogenic potential of chemicals by in vitro cell transformation assays.
日本環境変異原学会の論文
1998-07-21