ニトロアレーンの構造・変異活性相関およびヒト暴露の実態

概要

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Nitrobenzo[a]pyrenes(NBPs)and related nitroazabenzo[a]pyrenes(NABPs)are extraordinarily mutagenic to Salmonella typhimurium. 3-Nitro-6-azabenzo[a]pyene-N-oxide is especially mutagenic and the NABP was found to be a more potent mutagen than 1, 8-dinitropyrene. Mutagenicity of NBPs and NABPs was associated with the position of substitution of the nitro function when NO_2 was substituted at the third position on the BP and ABP structure. The mutagenicity of 22 nitrophenanthrenes and 19 nitroazaphenanthrenes was investigated, and these mutagens were activated by O-acetyltransferase esterification following nitroreductase and so were active against TA100 rather than TA98. Mutagenic nitropyrenes and polycyclic aromatic hydrocarbons(PAHs)were detected in resected lung specimens of Japanese lung cancer patients living in Fukuoka, and in lung specimens of Chinese patients who were living in areas of high risk for developing lung cancer in China.
1998-07-21