N-nitrosodimethylamineに対するカテキン類の変異原性抑制機構

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概要

• 論文の詳細を見る

• The purpose of this study was to clarify the mechanism of the inhibitory effect of catechins on NDMA-induced mutagenesis, which has been expressed by hydroxyl radical-dependent mono-oxygenation on NDMA, as previously reported. Catechin anti-mutagenesis was measured in Salmonella typhimurium TA100 with S9 from SD male rat liver, pre-treated with acetone and by fasting. The suppression of NDMA-induced mutagenesis by catechol-type and gallate-type catechins was approximately 30% and 100%, respectively. The results of voltammetry and coulometry of catechins revealed that the numbers of transferring electron of these catechins at an oxidizable potential of less than 550mV were around two for the former and five for the latter catechins. These values related closely to the percentage inhibition of mutation.

• 1998-04-10

著者

• 古川 秀之

  名城大学薬学部

• 江幡 淳子

  ジェフ野菜研

• 古川 秀之

  名城大 薬

• 深貝 尚子

  名城大学薬学部

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