DNA複製と細胞分裂を連動する分子機構(日本環境変異原学会第32回大会シンポジウム1「環境物質に対する生体応答の分子機構」)

概要

論文の詳細を見る
Chk1 is required for arrest of the mammalian cell cycle before mitosis in response to DNA damage or replication block. It is also implicated in regulation of cell cycle progression because it is essential for embryonic cell viability. With the use of mouse embryonic stem cells conditionally deficient in Chk1, we now show that this kinase is indispensable for the timing of mitotic initiation. Chk1 deficiency resulted in premature onset of mitosis through reduction of Cdc2 phosphorylation on Tyr^<15> as a result of increased Cdc25 activity and decreased Weel activity. Our results suggest that Chk1 regulates Cdc2 to establish proper timing of mitotic initiation during the mammalian embryonic cell cycle.
日本環境変異原学会の論文
2004-09-30