Functionalization of Pyridines via Reissert-Henze Reaction

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概要

• 論文の詳細を見る

• Reaction of Reissert-Henze salt with silver acetylide gave the pyridine ethynylated selectively at 2-position. 2-(Phenylethynyl)pyridines substituted 3-position with a carbonyl or masked carbonyl group were converted to various bicyclic pyridine derivatives by intramolecular cyclization. 3-Cyano-2-(phenylethynyl)pyridine was cyclized intramolecularly under acidic conditions to give the naphthyridine and pyranopyridine derivatives. 2-(Phenylethynyl)pyridine reacted with dimethyl acetylenedicarboxylate in the presence of a proton source to give indolizines having methoxycarbonyl groups at the 2- or 2,3-positions.

• 近畿大学の論文
• 1997-03-05

著者

• Ohshiro Yoshiki

  近畿大学理工学総合研究所

• Kikuta Hiroshige

  近畿大学

関連論文

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• Activities of 7-Azaindole Derivatives as Agricultural Fungicides
• Functionalization of 7-Azaindole
• Functionalization of Pyridines via Reissert-Henze Reaction
• Characteristic Reaction Mode of Cofactor PQQ toward Nucleophiles

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