輸液と総合ビタミン注射製剤の混合によりTPN投与セットにおける滴下速度の減少をもたらす原因の解明

概要

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It is well known that control ling the infusion rate is necessary, when administering total parenteral nutrition (TPN). We recently observed a significant reduction in the now rate caused by several brands of TPN administration using Hicaliq[○!R] RF (HRF) mixed with total vitamin injection. In the present study, we investigated the flow rate reduction echanism between several bands of TPN. The flow rate decreased in cases of TPN solution mixed with some vitamins for injection which contained lipophilic vitamins. These vitamins contained polyoxyethylene (20) sorbitan monooleate as a solubilizer of lipophilic vitamin. A reduction of the now rate was observed in the TPN administration sets using an in-line filter which has a symmetric membrane structure, whereas the filter of the asymmetric membrane structure in the TPN administration set did not show a flow rate reduction. The lowest now rate was observed in HRF, of all the TPN solutions used in the present study because 50% glucose in HRF showed a higher viscosity. There is possibility that an unstable now rate was obtained in the case of a positioning failure of the TPN bag caused by the patient, when administering HRF mixed with polyoxyethylene (20) sorbitan monooleate containing total vitamins for injection.
日本医療薬学会の論文
2003-04-10