アミノ酸配列に含まれる情報量の実験的検証 : タンパク質立体構造構築原理と分子進化の観点からの考察

概要

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A protein three-dimensional structure is essentially determined by its amino acid sequence, and thus by the information contained therein. Although "protein folders" have long studied what physical forces are important to stabilize a protein structure, it is only recently that one has experimentally asked the question: how much and what information is prerequisite for stabilizing a protein structure. Here, we describe two recent experiments in which the information contents of two protein sequences have been dramatically decreased and nevertheless the proteins remain active and natively structured. We discuss the implication of these findings both from a protein structure and a molecular evolution point of view.
日本生物物理学会の論文
2001-09-25