膜融合におけるリン脂質ダイナミクスと細胞骨格制御(<特集>細胞の膜系構築)

概要

論文の詳細を見る
Recent advances in molecular genetics have provided powerful tools for studying the biological function of proteins, resulting in rapid extension of our knowledge of their functions. However, little is still known about the organization and function of biological membranes, especially how membrane phospholipids are organized and participate in cellular function. This is mainly because of the lack of appropriate methodologies for either manipulating or tracing the function of membrane lipids. We have developed various probes to analyze the moleculaer motion and function of phospholipids in biological membranes. Our recent studies have shown that enhanced transbilayer movement of plasma membrane phosphatidylethanolamine plays a pivotal role in mediating coordinated movement between cytoskeletal proteins and plasma membrane to achieve successful cell dividion and membrane fusion.
日本生物物理学会の論文
1999-01-25