記憶シナプスの可塑性とインパルス頻度 : ATP, アデノシンの役割

概要

論文の詳細を見る
Synaptic connections in the brain are functionally and morphologically changed depending on environmental stimuli. A "tracing circuit" model is proposed that a "tracing circuit" of neurons corresponding to human descriptive memory is established by synaptic competition and kept by the following sprouting and increase of the number of synapses in the circuit. The physiological roles of adenosine derivatives are considered to be agonists of two mechanisms of synaptic competition : lateral inhibition and central facilitation. Released ATP can facilitate novel synapse formation through ecto-protein kinase. A new hypothesis is proposed that the occurance of long-term potentiation (LTP) or of long-term depression (LTD) depends on the frequency of conditional stimulation and can be induced by different presynaptic adenosine receptors.
日本生物物理学会の論文
1990-07-25