動物モデルよりみたうつ病

概要

論文の詳細を見る
1.Rats were conditioned by using sound as a conditioned simulus, and tetrabanazine as an unconditioned stimulus, andsponraneous locomotor activity as parameter of behavior. 2.A difinite period of motionlessness in rats appeared on presentation of a conditioned stimuluts alone, after a definite number of conditioning trials were repeated. 3.Pretreatment with imipramine made the conditioned motionlessness imperfect. 4.From these findings, this conditioned motionlessness was considered as an appropriate animal model of human depression. 5.Biochemical analyses of brain samples indicated that this motionlessness was due to an excess in functional activity serotonin.
日本心身医学会の論文
1978-04-01