IMMUNE RESPONSE TO ECHINOCOCCUS MULTILOCULARIS INFECTION IN THE MOUSE MODEL : A REVIEW
スポンサーリンク
概要
- 論文の詳細を見る
Echinococcus multilocularis is a cestode helminth which, along with E. granulosus, E. oligarthus and E. vogeli is a causative agent of hydatid disease in man. In the intermediate host (including man), cysts formed by the metacestode (larval stage) develop in the internal organs, causing functional impairment which often leads to the death of the host. In this review larval E. multilocularis infection in mice, the most popular experimental intermediate host, is examined, and the immune response to the organism is described in detail. Evidence is presented which suggests that cell-mediated immunity (CMI) plays a large role in suppression of larval growth. Congenitally athymic nude mice, and mice treated to remove thymocytes had high susceptibility to infection, while mice strains assessed as having high helper T lymphocyte function showed resistance to infection. The degree of antibody response shown by the host does not correlate with the susceptibility to E. multilocularis. Infection with E. multilocularis is accompanied by immunosuppression, manifested by inhibition of effector cell chemotaxis and receptor expression, suppressor macrophage and lymphocyte activity, decline in helper T-lymphocyte activity and immune-complex deposition.
- 北海道大学の論文
- 1992-09-30
著者
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Kamiya Masao
Dept. Of Veterinary Parasitology Faculty Of Veterinary Medicine Hokkaido University
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Playford Matthew
Dept. Of Veterinary Parasitology Faculty Of Veterinary Medicine Hokkaido University