Oxygen uptake effciency slope (OUES) : その生理学的基礎と臨床応用

概要

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Oxygen uptake efficiency slope (OUES) is a new index of cardiorespiratory functional researve derived from the logarithmic relation between oxygen uptake (VO2) and minute ventilation (VE) during incremental exercise. The OUES represents how effectively oxygen is extracted and taken into the body from the air ventilated. The physiological backgrounds of the index are based on (i) the development of metabolic acidosis that is controlled by the distribution of blood to the skeletal muscles, (ii) the physiologic dead space that is affected by the perfusion to the lungs, and (iii) arterial carbon dioxide partial pressure. One of the greatest advantages of the OUES is that it can be calculated by exercise data of submaximal levels. Another advantage is that it is mathematically determined from a set of gas analysis data and therefore is completely an objective measurement. Moreover, OUES is shown to be highly reproducible. Clinical applications of the OUES have been reported initially from a population of pediatric cardiology, then from adult patients with chronic heart failure and elite endurane athletes. Further applications are expected with the use of this sophisticated index.
東海大学の論文