アスピリンおよびアスピリンアルミニウムの添加物質による安定性の比較(1)

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The stability of aspirin (Asp) and aspirin aluminum (Asp-Al) has been studied at various relative humidity (R. H.) regarding their weight change and decomposition rate when antacids and diluents are mixed. Magnesium oxide (MgO), magnesium silicate (Mg-Sil), natural aluminum silicate (n-Al-Sil), synthetic aluminum silicate (s-Al-Sil) and potato starch (p-sta) were equivalently added to Asp and Asp-Al, respectively, and the successive daily changes were observed at temperature of 37℃ and R. H. of about 60%, 80% and 100%. The remarkable decompositions derived from humidification were observed in Asp+MgO and Asp+Mg-Sil. Especially, the former was almost completely decomposed at R. H. 100% after two days. Similarly, the rapid progress of decomposition was observed for Asp-Al+MgO and Asp-Al+Mg-Sil, Asp+s-Al-Sil, Asp-Al+s-Al-Sil and Asp-Al+n-Al-Sil were less humidified at each three degrees of R. H. and showed relative stability, while Asp+n-Al-Sil was remarkably decomposed in spite of its weight decrease at R. H. 60%. Asp+p-sta and Asp-Al+p-sta were scarcely decomposed regardless of their relatively high humidification rate. In the control test using Asp and Asp-Al solely, low humidification and little decomposition were observed. An interrelation between the decomposition rate constant of Asp and the humidification rate of mixed drug was observed on the mixture of MgO, Mg-Sil and s-Al-Sil with Asp, but no correlation was observed when n-Al-Sil was mixed with Asp. This seems to be caused from the specific interaction between Asp and n-Al-Sil.
共立薬科大学の論文
1983-03-25

アスピリンおよびアスピリンアルミニウムの添加物質による安定性の比較(1)

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