(松本大学地域総合研究センター研究員研究業績)
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概要
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Background/Objectives : This study was carried out, from the viewpoint of cost-effectiveness, the optimum number of fecal specimens to collect for use in immunochemical occult blood testing as a means of screening for colorectal cancer. Subjects and Methods: 3300 asymptomatic individuals were subjects of this study. They gave samples for an immunochemical fecal occult blood test, Monohaem and colonoscopy was carried out during a medical check-up. For evaluation of the optimal number of sampling specimens, the results of the first day of sampling, those of the first and second days, and those of the samples taken for three consecutive days were considered as a single-day method, a two-day method, and a three-day method respectively. The average costs per detection of one patient with colorectal cancer, and the detection rate and the false positive rate of these three fecal sample collection methods were evaluated. Results: The average costs for one cancer case detected were calculated as $3630.68 for a single-day method, $3350.65 for a two-day method, and $4136.36 for a three-day method, respectively. The detection rate and the false positive rate were calculated as 47% and 3.5% for a single-day method, 82% and 4.7 % for a two-day method, and 88% and 5.3% for a three-day method, respectively, indicating a significant difference in the detection rate between a single-day and a two-day methods, as well as a single-day and a three-day methods(p<0.05). No significant differences in the false positive rate among the three testing methods were observed. Conclusions: This analysis suggests that a two-day fecal collection method is recommended in immunochemical occult blood screening by Monohaem from the aspects of cost-effectiveness and diagnostic accuracy.
- 松本大学の論文
- 2002-10-01