Change of Bone Mechanical Strength in Rats after Spinal Cord Injury over a Short Term

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概要

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• This study investigated the time-course of changes in bone mechanical strength in rats with spinal cord injury (SCI). Sixty-four male Wistar rats underwent spinal cord transection at the thoracic nerve. Control rats underwent a sham procedure (SHAM). Animals were sacrificed at day 1, 4, 7 and 14 after operation. The mechanical strength of the left femur and tibia was measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. A specimen of right tibia was prepared and examined under a microscope. Bone mechanical strength, dry bone weight, and ash content of the femur and tibia in SCI rats were significantly lower than those in SHAM animals. Dry bone weight and ash content began to decrease from the 4th day after SCI and reached their lowest at day 7 after operation. Bone mechanical strength had reduced significantly by the 14th day. Gaps and spaces were observed in the trabecular area at the same time. After SCI, calcified cartilage decreased and the reduction of bone mass occurred rapidly. Moreover, a decline of bone mechanical strength is caused within 2 weeks. Thus, SCI led to the atrophy of bone and caused the reduction of mechanical strength at an early stage. It is thus necessary to prevent bone loss after SCI immediately.

• 広島大学の論文

著者

• Minematsu Akira

  Kio Univ. Nara Jpn

• Minematsu Akira

  Department Of Physical Therapy Kio University

• MAEJIMA HIROSHI

  Institute of Health Sciences, Hiroshima University School of Medicine

• YOSHIMURA OSAMU

  Institute of Health Sciences, Hiroshima University School of Medicine

• Yoshimura Osamu

  Hiroshima City Counseling Center For The Physically Disabled

• Yoshimura Osamu

  Institute Of Health Sciences Hiroshima University

• Minematsu Akira

  Department Of Physical Therapy Faculty Of Health Science Kio University

• Miyamoto Takahide

  Health Sciences Graduate School Of Medical Sciences Hiroshima University

• Moriyama Hideki

  School Of Health And Social Services Saitama Prefectural University

• Moriyama Hideki

  Division Of Physical Therapy And Occupational Therapy Sciences Graduate School Of Health Sciences Hi

• Maejima Hiroshi

  Graduate School Of Health Sciences Hiroshima University

• 前島 洋

  Health Sciences, Graduate School of Medical Sciences, Hiroshima University

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