高強度運動が血中Cu/Zn-SOD濃度とリンパ球中Cu/Zn-SODmRNA発現に及ぼす影響

概要

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The purpose of the present study was to investigate the effects of high intense exercise on Cu/Zn-superoxide dismutase (Cu/Zn-SOD) concentration in human plasma and Cu/Zn-SOD mRNA expression in human lymphocytes. A single bout of 80% VOamax exercise induced a significant increase of the Cu/Zn-SOD concentration in plasma (p<0.05), but did not affect the expression of Cu/Zn-SODmRNA in lymphocytes. The expression of Cu/Zn-SODmRNA in lymphocytes was measured at first, third and last day of a training camp for five days. The expression of Cu/Zn-SODmRNA in lymphocytes in last day of the camp was significantly increased, compared with those in both first and third day of the camp (p<0.01, and p<0.05, respectively). The results obtained in this study suggest that the increase in plasma Cu/Zn-SOD concentration after acute bout of exercise may be occurred by mechanisms of release from tissues into bloodstream. The results of this study also suggest that repeating high intense exercise may promote the expression of Cu/Zn-SODmRNA in lymphocytes and Cu/Zn-SOD activity in lymphocytes.
広島大学の論文
2003-03-28