EXPERIMENTAL STUDY OF LONG TERM OBSERVATION OF THE ECTOPIC BONE INDUCED BY rhBMP-2

概要

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Ectopic bone formed by BMP implantation has not been reported to retain permanently and believed to be absorbed with time. We quantitatively measured BMD of ectopically induced bone by rhBMP-2 using QCT method, and examined histopathological changes between 2 to 110 weeks after BMP implantation. The volumes of the induced bone were not so variant in every group. The BMD was significantly increased until 8 weeks after BMP implantation. The increase of calcification was remarkable between 4 to 8 weeks after implantation while the volumes were not so changed. No significance in BMD was observed after 8 weeks. Histpathological findings indicate that trabecular bone, thin cortical bone, osteocytes, and bone marrow were formed until 4 weeks. Trabecular part was reduced, cortical part was thickening, fatty marrow increased and there were less osteocytes and osteoclasts after 8 weeks. These results indicate that use of an appropriate carrier can allow ectopic bone formed by BMP implantation to be retained permanently.
名古屋市立大学の論文
2003-02-28