VASODILATIVE EFFECTS OF CARDIOTROPHIN-1 IN CHRONIC HYPOXIC AND PULMONARY HYPERTENSIVE RATS

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Cardiotrophin-1 (CT-1) reduces arterial blood pressure by activating nitric oxide synthesis, but it is unknown whether CT-1 acts on pulmonary vessels. This study was designed to elucidate the effect of CT-1 on pulmonary arteries of pulmonary hypertensive rats. Pulmonary hypertension was induced in rats in a hypoxic chamber containing 10-11% oxygen. Rats kept in the hypoxic environment received either recombinant mouse CT-1 at a concentration of 50μg/kg (CT-1 + hypoxia group, n=21) or phosphate-buffered saline (hypoxia group, n=30) once per day. Control rats housed in room air also received either the equivalent concentration of CT-1 (CT-1 + normoxia group, n=18) or phosphate-buffered saline (normoxia group n=39). Pulmonary arterial pressure and pulmonary vasorelaxation were measured. The mean pulmonary arterial pressures were as follows from lowest to highest: normoxia group (20.3±4.0 mmHg), CT-1+normoxia group (21.1±2.4 mmHg), CT-1+hypoxia group (27.9±4.1 mmHg), and hypoxia group (33.9±6.6 mmHg). The endothelium-dependent vasorelaxation value was largest in the normoxia group (59.5±17. 4 %), with it decreasing in the other groups in the following order: CT-1+normoxia group (52.8±15. 5%), CT-1+hypoxia group (42.3±14.8%), and hypoxia group (17.4±4.8%). The administration of CT-1 did not affeet morphological changes to the media of the pulmonary artery. Our results demonstrate that treatment with CT-1 in a chronic hypoxic pulmonary hypertension model protects the endothelial function of the pulmonary artery and decreases pulmonary arterial pressure.
名古屋市立大学の論文
2003-02-28

VASODILATIVE EFFECTS OF CARDIOTROPHIN-1 IN CHRONIC HYPOXIC AND PULMONARY HYPERTENSIVE RATS

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