Molecular Epidemiology of Rotaviruses
スポンサーリンク
概要
- 論文の詳細を見る
Molecular epidemiology of rotaviruses emerged a little over 25 years ago as a fascinating branch of science that utilized then cutting-edge technology of RNA polyacrylamide gel electrophoresis. Molecular epidemiology, as I have observed it closely almost since its dawn, is an ever-evolving discipline which has incorporated the advances of the related sciences including molecular evolutionary biology and ecology, while it is firmly and deeply rooted in the edifice of epidemiology of infectious diseases. Rotavirus is a non-enveloped virus possessing 11 segments of double-stranded RNA as the genome and belongs to the Reoviridae family. The consequences of rotavirus infections in terms of mortality are different depending on whether children live in the developing countries or they live in the developed countries, and this difference comes mostly from the availability of proper medical intervention. A second generation rotavirus vaccine has just been licensed in Mexico and will hopefully be used widely among countries where the burden of the disease is the highest. One potential threat to the existing and future rotavirus vaccines is the extreme diversity of strains circulating among children across the world, and it is the key to understand how rotaviruses maintain themselves in nature. Molecular epidemiology of rotaviruses helps address such questions and has demystified the way in which they evolve including interspecies transmission of rotaviruses. A few examples are provided from the work that my colleagues and I did over the course of my career in an attempt to give a feel of molecular epidemiology of rotaviruses.
- 長崎大学の論文
著者
-
NAKAGOMI Osamu
Department of Microbiology, Akita University School of Medicine
-
Nakagomi Osamu
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedica
-
Nakagomi Osamu
Department Of Microbiology Akita University School Of Medicine
関連論文
- Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
- Recombinant Human Monoclonal Fab Fragments against Rotavirus from Phage Display Combinatorial Libraries
- Genetic Variation in the VP4 and NSP4 Genes of Human Rotavirus Serotype 3 (G3 Type) Isolated in China and Japan
- The Relative Frequencies of G Serotypes of Rotaviruses Recovered from Hospitalized Children with Diarrhea:A 10-Year Survey(1987-1996)in Japan with a Review of Globally Collected Data
- A Lack of Consistent Amino Acid Substitutions in NSP4 between Rotaviruses Derived from Diarrheal and Asymptomatically-Infected Kittens
- Apparent Re-Emergence of Serotype G9 in 1995 among Rotaviruses Recovered from Japanese Children Hospitalized with Acute Gastroenteritis
- Molecular Epidemiology of Rotaviruses
- Much Higher Risk of Premalignant and Malignant Cervical Diseases in Younger Women Positive for HPV16 than in Older Women Positive for HPV16
- Rotavirus Vaccines:A Perspective
- The Bovine Lactophorin C-Terminal Fragment and PAS6/7 Were Both Potent in the Inhibition of Human Rotavirus Replication in Cultured Epithelial Cells and the Prevention of Experimental Gastroenteritis
- Genogroup Characterization of Reemerging Serotype G9 Human Rotavirus Strain 95H115 in Comparison with Earlier G9 and Other Human Prototype Strains
- Continued Circulation of G12P[6] Rotaviruses Over 28 Months in Nepal: Successive Replacement of Predominant Strains
- The Burden of Rotavirus Gastroenteritis among Japanese Children during Its Peak Months: an Internet Survey
- The First Identification of Rotavirus B from Children and Adults with Acute Diarrhoea in Kathmandu, Nepal
- A High Incidence of Intussusception Revealed by a Retrospective Hospital-Based Study in Nha Trang, Vietnam between 2009 and 2011