An Protective Mechanism against Hyperoxia induced Lipid Peroxidation in the Lung of Vitamin E-deficient Rats
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概要
- 論文の詳細を見る
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。The effects of hyperoxia on the levels of lung TBA-reactants (an index of lipid peroxidation), superoxide dismutase (SOD), and glutathione peroxidase (GSHpx) were studied in Vitamin E-deficient rats. Male weanling rats were maintained on Vitamin E-deficient or control (containing 2mg α-tocopherol per 1Kg diet) diets for 3 months. Compared to control rats, the concentrations of Vitamin E in plasma and lung of Vitamin E-deficient group were decreased one half, one twentieth, respectively. Vitamin E-deficient rats had TBA-reactants of 191.1% (p<0.01), GSHpx activity of 32.2% (p<0.001), and showed no alteration in SOD activity. (data expressed as percent of control values). Continuous exposure to 96% oxygen increased in the mortality of Vitamin E-deficient rats. Exposure to 96% oxygen for 24 hours elevated TBA-reactants (120%, p<0.05), as well as the activity of SOD (112.6%, p<0.05), and the activity of GSHpx (125.6%, P<0.02) in the lung of control rats. In Vitamin E-deficient rats, hyperoxia did not increase in the levels of TBA-reactants nor the activity of SOD. On the other hand, induction of GSHpx by hyperoxia was found in the lung of Vitamin E-deficient rats although the total activity was lower than that of controls. Thus, GSHpx seems to be more sensitive on the oxidative stress than SOD. The data in the present study suggest that Vitamin E and GSHpx have mutually dependent roles of the protective system against lipid peroxidation, and GSHpx have primary importance on the detoxification of peroxidation induced by hyperoxia.
- 京都大学の論文
- 1985-08-31
著者
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Sato K
Tokyo Univ. Agriculture And Technol. Tokyo Jpn
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SATO Kimihiko
The Department of Clinical Pulmonary Physiology, Chest Disease Research Insjitute, Kyoto University
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