<原著>〔I〕低温下の抗菌力 / 〔II〕ガス曝露下の抗菌力(第 4 編 結核菌の発育に不適当な条件と R. P. の抗菌力)(Griselimycine の半合成誘導体 27753RP の抗結核作用に関する試験管内実験的検討)
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この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。(I) Antituberculous activities of R. P under low temperature. The antituberculous activities of R. P against Mycobacterium tuberculosis H37Rv strain at 4℃ or 25℃ were investigated using SSC method. 1. Bacteriostatic effect When the cultures were incubated at 4℃ or 25℃, there was no growth of tubercle bacilli. But at 37℃, the MIC of R.P was 0.156mcg/ml; SM, 1.563mcg/ml; RFP, 0.078mcg/ml, respectively. The bacteriostatic effect of R. P. was inferior than that of RFP, but it was superior to that of SM. 2. Bactericidal effect At 37℃, the MBC of R. P was 0.313mcg/ml; SM, 12.5mcg/ml; RFP, 0.313mcg/ml, respectively. Bactericidal effect of R. P was inferior to that of RFP, but superior to that of SM. There was no difference of the bactericidal effect of R. P between at 37℃ and at 25℃, so the bactericidal effect of R. P was fairly potent. (II) Anituberculous Activities of R. P in Vitro under Several Kinds of Gas Exposures. The antituberculous activities of R. P to tubercle bacilli (H37Rv strain) were evaluated in vitro by replacing the air with N_2 and CO_2 gases. The experiments were performed by using SSC method with Kirchner's liquid medium. The results obtained are as follows : 1. There was no growth of tubercle bacilli in any sample, regardless of the kind of drug or gas during continuous exposure for four weeks. 2. With the CO_2 gas exposure, R. P, SM, and RFP showed remarkably strong bactericidal effects. The bactericidal effects of R. P was superior to that of SM, and similar to that of RFP. 3. Under N_2 gas exposure, the bactericidal effects of R. P and SM were less than those under CO_2 gas exposure. With the increase of drug concentrations, the bactericidal effects of these drugs increased under N_2 and CO_2 gas exposures.
- 京都大学の論文
- 1984-08-31
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