加齢がストレス反応に及ぼす影響 : 尾部懸垂雌ラットにおけるストレス関連ホルモンの変動

概要

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The endocrine response to stress is different between young and old rats. We determined urinary excretions of stress hormones as useful indices to evaluate the response to stress in tail-suspended rats, because it is possible to obtain the samples without inducing further stress in the animals. Urinary excretions of corticosterone and catecholamines were measured in order to evaluate the age-related difference in response to stress evoked by tail-suspension. It was demonstrated that (1) basal excretions of corticosterone and catecholamines in old rats (18-month-old-rats) were higher than those in young rats (8-week-old-rats). (2) In old rats urinary excretion of adrenaline was increased by the tail suspension as that in young rats. However, there were no differences in the urinary excretions of corticosterone and noradrenaline between suspended and non-suspended rats. (3) In the 12-month-old rats (middle aged rats), basal excretion of corticosterone and catecholamines and responsiveness of these hormones to stress were found to be between those of young rats and old rats.
1999-03-10