新規の腫瘍マーカーMOS-1抗原の膵臓癌に対する特異性と臨床診断での有用性の検討

概要

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We performed clinical and immunohistochemicalstudies on MOS-1antigen,a newmarker for pancreatic cancers.The antigen was detected by a new monoclonal antibody,MOS-1,An enzyme immunoassay was devised to measure the value of the MOS-1antigen in serum. Serum Values of MOS-1antigen exceedingthe mean plus three standard deviations for 134 healthy control blood samples were found in a high proportion of patients with pancreatic cancer (71%). The MOS-1antigen values in serum from patients with benign diseases,including chronic pancreatitis,were within the normal range in 95% of the cases. Furthermore,imunohistochemical analysis indicated that MOS-1 antigen was detected in pancreas cancer,bile duct cancer,and colon cancer. However,it was seldom detected in esophagus cancer,stomach cancer,lumg cancer nor in normal cells. Our data suggested that MOS-1antigen maybe useful in the diagnosis,management,and prognosis of patients with panecreatic cancer.
札幌医科大学の論文
1998-04-01