<原著>局所麻酔薬"塩酸リドカイン"はキサンチン酸化酵素の存在下で酸素ラジカル種を発生する

概要

論文の詳細を見る
This study investigated whether or not lidocaine, one of the most widely used local anesthetics in dentistry, reacts with xanthine oxidase and generates superoxide radicals (O_2^<・->) and/or some other oxygen radicals. A lidocaine-xanthine oxidase (LHC-XOD) reaction system was employed to make this experiment. Detection and measurement of the radicals were carried out by ESR spin trapping techniques using DMPO and M_4PO. Identification of DMPO and M_4PO adduct signals was performed by obtaining the hyperfine coupling constants (hfcc). When lidocaine was added to the LHC-XOD reaction system, the formation of O_2^<・-> and two other radicals were observed. From their hfcc, these two other radicals were identified to be acyl and acyloxyl radical adducts. However, in the absence of XOD, there was no radical generation. The results obtained show that the local anesthetic "Lidocaine" reacts with xanthine oxidase and generates superoxide, acyl and acyloxyl radicals.
北海道医療大学の論文
2002-12-31