<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について

概要

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To observe the effect of Hepatocyte growth factor/scatter factor (HGF/SF) on the invasion and metastasis of human oral squamous cell carcinoma (SCO cells, the invasive ability and internal signal transduction were examined The invasive ability of tumor cells (SAS, HSC-3,Ca9-22) was enhanced dose-dependently by HGF/SF stimulation, and C3 exoenzyme which is a specific inhibitor of Rho activation significantly reduced the invasive ability of SAS cells The HGF/SF stimulation enhanced the tyrosin phosphorylation of HGF receptors (c-Met) and focal adhesion kmase (FAK^<p125>) of SAS cells, and C3 exoenzyme completely inhibited the activation of FAK^<p125> It was observed that Rho protein located around the nuclear area translocated to the membrane area and subsequently increased in the cytolysate, following HGF/SF stimulation These results suggest that the activation of FAK^<p125> caused by phosphorylation of c-Met may enhance the HGF/SF, inducing invasive ability and that Rho protein possibly regulates the activation of FAK^<p125> through the translocation itself
北海道医療大学の論文
1999-12-30