<原著>Aminoacetonitrileによる顎骨の実験的Osteolathyrismに対する成長ホルモン投与の影響

概要

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In order to examine the lathyrogenic effects using aminoacetonitrile together with growth hormone, the writer studied the periodontal and condylar tissues in 40 rats with histologic techniques. Experimental animals were divided into 4 groups as follows : Group A : 10 rats were injected moderate doses of aminoacetonitrile every day for 3 weeks. Group B and D : Rats were injected aminoacetonitrile with the above mentioned method together with injections of growth hormone every other day. Group C : 10 rats were injected aminoacetonitrile and growth hormone in the same manner as Group B and D after extirpation of the pituitary gland. After 3 weeks, the writer recognized synergetic effects of growth hormone that accelerated the lathyrogenic response in mandibles. The writer observed remarkable atrophic changes in periodontal tissues, destruction of hyaline cartilage zone, calcified zone and primary spongiosa in condyle, and bone proliferation in the muscle inserted area of the mandible.
北海道医療大学の論文
1984-12-31